Wednesday, January 2, 2008

Founder of a Cancerous Genetic Disorder

If you have polyps and are wondering if you belong to the family with the colorectal founder gene, I would imagine that these are people who would have settled on the Connecticut River or other areas where the Dutch did not have settlements. That thesis is dependent on the family being English and not Dutch. If they sailed from England, the assumption is that they were English. Well, at least it is a start to help you learn more.
clipped from


Colon cancer risk traced to common ancestor

By Michael Kahn
Wed Jan 2, 12:15 AM ET

LONDON (Reuters) -
A married couple who sailed to America
from England around 1630 are the reason why thousands of people
in the United States are at higher risk of a hereditary form of
colon cancer, researchers said on Wednesday.

Using a genetic fingerprint, a U.S. team traced back a
so-called founder genetic mutation to the couple found among
two large families currently living in Utah and New York.

The U.S. team first focused on the Utah branch of the
family -- numbering about 5,000 people today -- 14 years ago
because its members had an unusually high risk of colon cancer.

Because the family was Mormon, the researchers were able to
mine a wealth of genealogical information taken from detailed
church records over the years that is now part of a large
genetics database in Utah, Neklason said.

related to the Utah
part of the family, the researchers eventually identified the
New York branch
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